| Numéro |
MATEC Web of Conferences
Volume 4, 2013
ICOMF14 – 14th International Conference on Organized Molecular Films (LB 14)
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|---|---|---|
| Numéro d'article | 05001 | |
| Nombre de pages | 4 | |
| Section | Self-Assembly and Nanoscale Organization | |
| DOI | https://doi.org/10.1051/matecconf/20130405001 | |
| Publié en ligne | 13 août 2013 | |
Bioesterified polysubstituted-cyclodextrin/surfactant nanoparticles obtained by multilevel self-assembly
1 CNRS UMR 8612 Institut Galien Paris-Sud, Univ Paris-Sud 11, 92296 Châtenay-Malabry, France
2 DPM, CNRS UMR 5063, ICMG FR 2607, UFR of Pharmacy, University of Grenoble, France
* e-mail: Angelina.Angelova@u-psud.fr
The purpose of this work is to investigate the inclusion complexation between a novel amphiphilic biotransesterified cyclodextrin (CD), incorporated in nanostructured environment, and a model drug compound. A water-insoluble γ-cyclodextrin derivative (γ-CD-C10), polysubstituted with multiple (n=7-8) decanoyl chains (C10) on the secondary face, is produced by enzymatically-assisted esterification. The γ-CD-C10 derivative is embedded in amphiphilic nanoenvironment created by self-assembly with the lipophilic dye Nile red (NR) and the non-ionic surfactant polysorbate 80 (P80). The inclusion complexation and the environmental effects upon the γ-CD-C10/NR/P80 nanoparticle (NP) formation, in a multilevel self-assembly approach, are investigated by means of steady-state fluorescence and Förster resonance energy transfer (FRET) techniques. Quasi-elastic light scattering (QELS) is used to control the NP size distribution during the sequential steps of the assembling process.
© Owned by the authors, published by EDP Sciences, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.